ABT1 Gene Summary [Human]
Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ABT1 |
| Official Name | activator of basal transcription 1 [Source:HGNC Symbol;Acc:HGNC:17369] |
| Ensembl ID | ENSG00000146109 |
| Bio databases IDs | |
| Aliases | activator of basal transcription 1 |
| Synonyms | activator of basal transcription 1, Esf2, hABT1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ABT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- transcription regulator
- transcription co-activator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ABT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- positive regulation of transcription, DNA-dependent
- endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- small-subunit processome assembly
- spinal cord motor neuron differentiation
- transcription from RNA polymerase II promoter
- endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- nucleolus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- transcription coactivator activity