Dennd3 Gene Summary [Mouse]
Enables guanyl-nucleotide exchange factor activity. Involved in endosome to lysosome transport and protein catabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytoplasmic vesicle. Orthologous to human DENND3 (DENN domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dennd3 |
| Official Name | DENN/MADD domain containing 3 [Source:MGI Symbol;Acc:MGI:2146009] |
| Ensembl ID | ENSMUSG00000036661 |
| Bio databases IDs | |
| Aliases | DENN/MADD domain containing 3 |
| Synonyms | DENN domain containing 3, E030003N15Rik, RGD1311559 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dennd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- DENN (AEX-3) domain
- guanyl-nucleotide exchange factor
- Stabilization of polarity axis
- dDENN domain
- WD40
- uDENN domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Crohn disease
- latent tuberculosis
- Alzheimer disease
- COVID-19
- stuttering
- non-small cell lung cancer
- Hirschsprung disease 1
role in cell
- autophagy by
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dennd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of Rab protein signal transduction
- protein catabolic process
- endosome to lysosome transport
Cellular Component
Where in the cell the gene product is active
- cytosol
- cytoplasmic vesicle
Molecular Function
What the gene product does at the molecular level
- guanyl-nucleotide exchange factor activity