Dvl2 Gene Summary [Mouse]
Enables several functions, including enzyme binding activity; frizzled binding activity; and identical protein binding activity. Involved in several processes, including heart morphogenesis; positive regulation of GTPase activity; and positive regulation of JUN kinase activity. Acts upstream of or within several processes, including Wnt signaling pathway, planar cell polarity pathway; embryonic morphogenesis; and positive regulation of protein tyrosine kinase activity. Located in several cellular components, including apical part of cell; clathrin-coated vesicle; and lateral plasma membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Used to study dextro-looped transposition of the great arteries. Orthologous to human DVL2 (dishevelled segment polarity protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dvl2 |
| Official Name | dishevelled segment polarity protein 2 [Source:MGI Symbol;Acc:MGI:106613] |
| Ensembl ID | ENSMUSG00000020888 |
| Bio databases IDs | |
| Aliases | dishevelled segment polarity protein 2 |
| Synonyms | dishevelled segment polarity protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dvl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- DIX domain
- Domain present in PSD-95, Dlg, and ZO-1/2
- protein kinase binding
- nuclear export signal
- frizzled binding
- protein binding activity, bridging
- canonical PDZ domain
- enzyme binding
- protein domain specific binding
- protein binding
- PDZ domain
- identical protein binding
- Segment polarity protein dishevelled (Dsh) C terminal
- DEP
- Dishevelled specific domain
Pathways
Biological processes and signaling networks where the Dvl2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- epithelial neoplasia
- cancer
- chronic lymphocytic leukemia
- hepatocellular carcinoma
- liver cancer
- persistent truncus arteriosus
- gastrointestinal neoplasia
- Alzheimer disease
role in cell
- proliferation
- apoptosis
- binding in
- expression in
- phosphorylation in
- growth
- differentiation
- activation in
- formation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- aggresome
- apical compartment
- cell cortex
- Nucleus
- Plasma Membrane
- basal bodies
- cytosol
- lateral plasma membrane
- nucleoplasm
- nuclear bodies
- spindle pole
- cytoplasmic vesicles
- endocytotic vesicle
- cleavage furrow
- kinetochores
- perikaryon
- presynaptic terminals
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dvl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JUN kinase activity
- planar cell polarity pathway involved in neural tube closure
- cochlea morphogenesis
- protein localization
- outflow tract morphogenesis
- convergent extension involved in neural plate elongation
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- regulation of cell proliferation
- segment specification
- heart development
- regulation of actin cytoskeleton organization
- neural tube closure
- positive regulation of JNK cascade
- positive regulation of protein phosphorylation
- heart looping
- canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway, planar cell polarity pathway
- intracellular signal transduction
- non-canonical Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- lateral plasma membrane
- nuclear body
- apical part of cell
- cytoplasm
- cytoplasmic vesicle
- cytosol
- clathrin-coated endocytic vesicle
- aggresome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- frizzled binding
- identical protein binding
- protein domain specific binding
- protein binding
- small GTPase binding
- protein binding, bridging