Mapkapk3 Gene Summary [Mouse]
Predicted to enable calmodulin binding activity; mitogen-activated protein kinase binding activity; and protein serine/threonine kinase activity. Involved in macropinocytosis; response to lipopolysaccharide; and toll-like receptor signaling pathway. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; naris; skin; urinary system; and ventral grey horn. Human ortholog(s) of this gene implicated in patterned macular dystrophy 3. Orthologous to human MAPKAPK3 (MAPK activated protein kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mapkapk3 |
| Official Name | mitogen-activated protein kinase-activated protein kinase 3 [Source:MGI Symbol;Acc:MGI:2143163] |
| Ensembl ID | ENSMUSG00000032577 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase-activated protein kinase 3 |
| Synonyms | 3PK, AI874665, MAPK activated protein kinase 3, MAPKAP3, Mapkap kinase 3, MapkKapk3, MDPT3, mitogen-activated protein kinase-activated protein kinase 3, MK-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mapkapk3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- MAP kinase kinase
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- MAPK binding site
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Mapkapk3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- delayed hypersensitive reaction
- epithelial cancer
- epithelial neoplasia
- cancer
- pancreatic cancer
- digestive system cancer
- abdominal cancer
- insomnia
- acute proliferative glomerulonephritis
role in cell
- activation in
- phosphorylation in
- expression in
- apoptosis
- production in
- transcription in
- dissociation
- translocation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mapkapk3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- toll-like receptor signaling pathway
- response to cytokine stimulus
- MAPK cascade
- vascular endothelial growth factor receptor signaling pathway
- macropinocytosis
- signal transduction
- protein autophosphorylation
- response to lipopolysaccharide
- peptidyl-serine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- protein binding
- MAP kinase kinase activity
- calmodulin-dependent protein kinase activity
- mitogen-activated protein kinase binding
- protein serine/threonine kinase activity
- calcium-dependent protein serine/threonine kinase activity