C1ql2 Gene Summary [Mouse]
Enables identical protein binding activity. Involved in neurotransmitter receptor localization to postsynaptic specialization membrane; postsynaptic density assembly; and regulation of synapse maturation. Located in extracellular region. Part of protein-containing complex. Is active in cerebellar climbing fiber to Purkinje cell synapse; hippocampal mossy fiber to CA3 synapse; and synaptic cleft. Is expressed in several structures, including brain; genitourinary system; gut; liver; and lung. Orthologous to human C1QL2 (complement C1q like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | C1ql2 |
| Official Name | complement component 1, q subcomponent-like 2 [Source:MGI Symbol;Acc:MGI:3032521] |
| Ensembl ID | ENSMUSG00000036907 |
| Bio databases IDs | |
| Aliases | complement component 1, q subcomponent-like 2 |
| Synonyms | Adii, C1QTNF10, complement C1q like 2, complement component 1, q subcomponent-like 2, CTRP10, Loc165257 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse C1ql2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- identical protein binding
- C1q domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- synapse
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse C1ql2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synapse maturation
- postsynaptic density assembly
Cellular Component
Where in the cell the gene product is active
- synaptic cleft
- collagen
Molecular Function
What the gene product does at the molecular level
- identical protein binding