C1ql4 Gene Summary [Mouse]
Enables identical protein binding activity. Acts upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of fat cell differentiation; and negative regulation of fibroblast proliferation. Located in extracellular space. Is expressed in several structures, including brain; genitourinary system; gut; liver; and lung. Orthologous to human C1QL4 (complement C1q like 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | C1ql4 |
| Official Name | complement component 1, q subcomponent-like 4 [Source:MGI Symbol;Acc:MGI:3579909] |
| Ensembl ID | ENSMUSG00000001076 |
| Bio databases IDs | |
| Aliases | complement component 1, q subcomponent-like 4 |
| Synonyms | Adik, C1QTNF11, complement C1q like 4, complement component 1, q subcomponent-like 4, CTRP11, RGD1565968 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse C1ql4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- identical protein binding
- C1q domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- impaired glucose tolerance
regulated by
role in cell
- expression in
- phosphorylation in
- proliferation
- differentiation
- production in
- signaling in
- clonal expansion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse C1ql4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ERK1 and ERK2 cascade
- fibroblast proliferation
- negative regulation of fibroblast proliferation
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of fat cell differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- collagen
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding