Erfe Gene Summary [Mouse]
Enables hormone activity and identical protein binding activity. Involved in several processes, including negative regulation of autophagy; negative regulation of osteoblast differentiation; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within positive regulation of fatty acid transport and regulation of fatty acid metabolic process. Located in extracellular space. Orthologous to human ERFE (erythroferrone). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Erfe |
| Official Name | erythroferrone [Source:MGI Symbol;Acc:MGI:3606476] |
| Ensembl ID | ENSMUSG00000047443 |
| Bio databases IDs | |
| Aliases | erythroferrone |
| Synonyms | 4832406C22, C1QTNF15, CTRP15, erythroferrone, FAM132B, LOC100364890, myonectin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Erfe often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hormone
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Erfe gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- liver cancer
- epithelial cancer
- organismal death
- hepatocellular carcinoma
- cervical cancer
- breast cancer
- thalassemia intermedia
- ovarian cancer
- esophageal cancer
role in cell
- expression in
- quantity
- apoptosis
- phosphorylation in
- differentiation
- signaling in
- diameter
- size
- formation
- autophagy by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Nucleus
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Erfe gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of fatty acid transport
- positive regulation of insulin receptor signaling pathway
- signal transduction
- negative regulation of gluconeogenesis
- positive regulation of glucose import
- negative regulation of osteoblast differentiation
- cellular iron ion homeostasis
- fatty acid transport
- negative regulation of apoptotic process
- negative regulation of autophagy
- negative regulation of osteoclast differentiation
- establishment of localization in cell
- positive regulation of protein kinase B signaling cascade
- regulation of fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- hormone activity