Kcnmb2 Gene Summary [Mouse]
Predicted to enable calcium-activated potassium channel activity and potassium channel regulator activity. Predicted to be involved in detection of calcium ion; neuronal action potential; and potassium ion transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Is expressed in acoustic ganglion; ascending aorta; and ductus arteriosus. Orthologous to human KCNMB2 (potassium calcium-activated channel subfamily M regulatory beta subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnmb2 |
| Official Name | potassium large conductance calcium-activated channel, subfamily M, beta member 2 [Source:MGI Symbol;Acc:MGI:1919663] |
| Ensembl ID | ENSMUSG00000037610 |
| Bio databases IDs | |
| Aliases | potassium large conductance calcium-activated channel, subfamily M, beta member 2 |
| Synonyms | 2700049B16RIK, 3110031N04Rik, KCMB2, LOC730067, potassium calcium-activated channel subfamily M regulatory beta subunit 2, potassium calcium-activated channel subfamily M regulatory β subunit 2, potassium large conductance calcium-activated channel, subfamily M, beta member 2, potassium large conductance calcium-activated channel, subfamily M, β member 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnmb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- KCNMB2, ball and chain domain
- ion channel inhibitor
- Calcium-activated potassium channel, beta subunit
- potassium channel regulator
- calcium-activated potassium channel
- protein binding
- ion channel
Pathways
Biological processes and signaling networks where the Kcnmb2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrial fibrillation
- atrial flutter
- insomnia
- dementia
- cutaneous lupus erythematosus
- childhood acute lymphoblastic leukemia
- bipolar disorder
- schizophrenia
regulated by
- DNMT1
- tedisamil
- INI-43
regulates
- Ca2+
- K+
- ion channel
role in cell
- action potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnmb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- detection of calcium ion
- potassium ion transmembrane transport
- regulation of action potential
- regulation of vasoconstriction
- regulation of action potential in neuron
Cellular Component
Where in the cell the gene product is active
- voltage-gated potassium channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium-activated potassium channel activity
- protein binding
- ion channel inhibitor activity
- potassium channel regulator activity