Atp1a3 Gene Summary [Mouse]
Enables P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential and heparan sulfate proteoglycan binding activity. Involved in several processes, including intracellular sodium ion homeostasis; regulation of cardiac muscle cell membrane potential; and sodium ion export across plasma membrane. Acts upstream of or within several processes, including intracellular signaling cassette; learning or memory; and nervous system development. Located in several cellular components, including neuron to neuron synapse; photoreceptor inner segment; and sarcolemma. Part of sodium:potassium-exchanging ATPase complex. Is active in cell surface. Is expressed in several structures, including alimentary system; early conceptus; gonad; heart; and nervous system. Used to study alternating hemiplegia of childhood and bipolar disorder. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; bipolar disorder; developmental and epileptic encephalopathy 99; dystonia 12; and epilepsy. Orthologous to human ATP1A3 (ATPase Na+/K+ transporting subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp1a3 |
| Official Name | ATPase, Na+/K+ transporting, alpha 3 polypeptide [Source:MGI Symbol;Acc:MGI:88107] |
| Ensembl ID | ENSMUSG00000040907 |
| Bio databases IDs | |
| Aliases | ATPase, Na+/K+ transporting, alpha 3 polypeptide |
| Synonyms | AHC2, ATP1A1, Atpa1a3, Atpa-2, ATPase, Na+/K+ transporting, alpha 3 polypeptide, ATPase Na+/K+ transporting subunit alpha 3, ATPase Na+/K+ transporting subunit α 3, ATPase, Na+/K+ transporting, α 3 polypeptide, CAPOS, DEE99, DYT12, Na+/K+ ATPase alpha3, Na/K ATPase subunit α 3, Na,K-ATPase α subunit 3, RDP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp1a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cation transporter/ATPase, N-terminus
- sarco/endoplasmic reticulum calcium-translocating P-type ATPase
- heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase
- golgi membrane calcium-translocating P-type ATPase
- G-protein-coupled receptor binding
- Na+/K+-exchanging ATPase
- heavy metal translocating P-type ATPase
- protein binding
- beta-amyloid binding
- plasma-membrane proton-efflux P-type ATPase
- E1-E2 ATPase
- copper-(or silver)-translocating P-type ATPase
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- plasma-membrane calcium-translocating P-type ATPase
- binding protein
- extracellular loop
- Na,H/K antiporter P-type ATPase alpha subunit
- potassium and/or sodium efflux P-type ATPase, fungal-type
- chaperone binding
- Cation transport ATPase (P-type)
- Haloacid Dehalogenase-like Hydrolases
- transporter
- Cation transporting ATPase, C-terminus
Pathways
Biological processes and signaling networks where the Atp1a3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nausea and vomiting
- vomiting
- edema
- dystonia
- atrial fibrillation
- CAPOS syndrome
- dystonia type 12
- alternating hemiplegia of childhood 2
- schizophrenia
- agitation
role in cell
- phosphorylation in
- morphology
- assembly
- depolarization
- transmission
- retention in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- Cytoplasm
- cell surface
- postsynaptic region
- cellular membrane
- Nucleus
- sarcoplasmic reticulum
- Golgi Apparatus
- Endoplasmic Reticulum
- microsome
- presynaptic membrane
- caveolae
- dendritic spine neck
- dendritic spine head
- myelin sheath
- synaptosomes
- synapse
- photoreceptor inner segments
- sarcolemma
- membrane processes
- perikaryon
- axons
- dendrites
- axon terminals
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp1a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to steroid hormone stimulus
- cellular potassium ion homeostasis
- regulation of resting membrane potential
- establishment or maintenance of transmembrane electrochemical gradient
- cellular sodium ion homeostasis
- cell communication by electrical coupling involved in cardiac conduction
Cellular Component
Where in the cell the gene product is active
- photoreceptor inner segment membrane
- sodium:potassium-exchanging ATPase complex
- endoplasmic reticulum
- Golgi apparatus
- neuronal cell body membrane
- neuronal cell body
- synapse
- organelle membrane
- plasma membrane
- membrane
- photoreceptor inner segment
- axon
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- sodium:potassium-exchanging ATPase activity
- metal ion binding
- chaperone binding
- beta-amyloid binding