Tlcd2 Gene Summary [Mouse]

Predicted to be involved in several processes, including membrane assembly; phospholipid homeostasis; and regulation of membrane lipid distribution. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system and retina. Orthologous to human TLCD2 (TLC domain containing 2). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Processed Transcript
Official Symbol
Tlcd2
Official Name
TLC domain containing 2 [Source:MGI Symbol;Acc:MGI:1917141]
Ensembl ID
ENSMUSG00000038217
Bio databases IDs NCBI: 380712 Ensembl: ENSMUSG00000038217
Aliases TLC domain containing 2
Synonyms RGD1562631, TLC domain containing 2
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tlcd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • TLC domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
  • 18:1/18:2 phosphatidylethanolamine
  • 18:1/22:6 phosphatidylethanolamine
  • 16:1(9Z)/16:1(9Z) phosphatidylethanolamine
  • 16:1/18:2 phosphatidylethanolamine
  • 16:1/20:4 phosphatidylethanolamine
  • 18:1/20:4 phosphatidylethanolamine
  • phospholipid
regulated by
disease
  • diet-induced nonalcoholic steatohepatitis
role in cell
  • assembly
  • organization

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Tlcd2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • plasma membrane organization
  • regulation of membrane lipid distribution
  • membrane assembly
  • phospholipid homeostasis

Cellular Component

Where in the cell the gene product is active
  • plasma membrane

Gene-Specific Assays for Results You Can Trust

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