Tspan1 Gene Summary [Mouse]
Predicted to be involved in protein stabilization. Predicted to be located in several cellular components, including nucleoplasm; perinuclear region of cytoplasm; and vesicle. Predicted to be active in plasma membrane. Is expressed in central nervous system; gut; and retina nuclear layer. Orthologous to human TSPAN1 (tetraspanin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tspan1 |
| Official Name | tetraspanin 1 [Source:MGI Symbol;Acc:MGI:1914055] |
| Ensembl ID | ENSMUSG00000028699 |
| Bio databases IDs | |
| Aliases | tetraspanin 1 |
| Synonyms | 9030418M05Rik, NET1, Tetraspanin 1, TETRASPANIN TM4-C, Tetraspan NET-1, TM4C, TM4SF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tspan1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tetraspanin_LEL
- protein binding
Pathways
Biological processes and signaling networks where the Tspan1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- intracellular membrane-bounded organelle
- perinuclear region
- cellular membrane
- Plasma Membrane
- vesicles
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tspan1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- vesicle
- cell junction
- plasma membrane
- lysosomal membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding