Kash5 Gene Summary [Mouse]
Enables dynein complex binding activity and identical protein binding activity. Involved in cytoskeleton organization; spindle localization; and telomere localization. Acts upstream of or within several processes, including double-strand break repair via homologous recombination; homologous chromosome segregation; and spermatogenesis. Located in chromosome; meiotic spindle pole; and nuclear outer membrane. Part of meiotic nuclear membrane microtubule tethering complex. Is expressed in ovary; primary spermatocyte; spermatocyte; and testis. Human ortholog(s) of this gene implicated in primary ovarian insufficiency and spermatogenic failure 88. Orthologous to human KASH5 (KASH domain containing 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kash5 |
| Official Name | KASH domain containing 5 [Source:MGI Symbol;Acc:MGI:2687329] |
| Ensembl ID | ENSMUSG00000038292 |
| Bio databases IDs | |
| Aliases | KASH domain containing 5 |
| Synonyms | CCDC155, Ccdc155-ps1, DKFZp434A2223, FLJ32658, Gm1434, KASH domain containing 5, POF22, RGD1561972, SPGF88 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kash5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Coiled-coil region of CCDC155 or KASH
- Fez1
- EF-hand domain
- binding protein
- Ciliary protein causing Leber congenital amaurosis disease
- Growth-arrest specific micro-tubule binding
- Uso1 / p115 like vesicle tethering protein, C terminal region
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- premature ovarian failure type 22
- azoospermia
- spermatogenic failure 88
- familial premature ovarian failure
regulated by
- methamphetamine
- KDM2A
regulates
- NFkB (complex)
- Cytoplasmic Dynein-1
role in cell
- apoptosis
- activation in
- number
- assembly
- localization
- abnormal morphology
- organization
- synapsis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- outer nuclear membrane
- spindle pole
- synaptonemal complexes
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kash5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spindle localization
- spindle assembly
- meiotic telomere clustering
- telomere localization
- oogenesis
- spermatogenesis
- double-strand break repair via homologous recombination
- actin filament organization
- chromosome localization to nuclear envelope involved in synapsis
- synapsis
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- lateral element
- nuclear outer membrane
- SUN-KASH complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- dynein complex binding