Trp53inp2 Gene Summary [Mouse]
Enables ubiquitin binding activity. Acts upstream of or within several processes, including osteoblast differentiation; tissue homeostasis; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in autophagosome and nucleus. Is expressed in several structures, including 1st branchial arch; facial prominence; limb mesenchyme; nervous system; and otocyst. Orthologous to human TP53INP2 (tumor protein p53 inducible nuclear protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trp53inp2 |
| Official Name | transformation related protein 53 inducible nuclear protein 2 [Source:MGI Symbol;Acc:MGI:1915978] |
| Ensembl ID | ENSMUSG00000038375 |
| Bio databases IDs | |
| Aliases | transformation related protein 53 inducible nuclear protein 2 |
| Synonyms | 1110029F20Rik, C20orf110, dJ1181N3.1, DOR, PIG-U, PINH, transformation related protein 53 inducible nuclear protein 2, Trp53inp2, tumor protein p53 inducible nuclear protein 2, tumour protein p53 inducible nuclear protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trp53inp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DOR family
- ubiquitin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute spinal cord injury
- colorectal adenoma
- colorectal adenoma formation
regulated by
- lipopolysaccharide
- BECN2
- CCND1
- dihydrotestosterone
- 3,5-dihydroxyphenylglycine
- bleomycin
- metribolone
- acetate
- E1
- Hel
regulates
role in cell
- proliferation
- migration
- differentiation
- assembly
- invasion by
- autophagy in
- macroautophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trp53inp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tissue homeostasis
- autophagic vacuole assembly
- positive regulation of transcription, DNA-dependent
- osteoblast differentiation
- protein localization
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- cytosol
- cytoplasmic vesicle
- autophagic vacuole
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding