Rack1 Gene Summary [Mouse]
Enables ion channel inhibitor activity. Involved in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide. Acts upstream of or within pigmentation and translation. Located in cytoplasm; dendrite; and neuronal cell body. Part of small ribosomal subunit. Is expressed in several structures, including central nervous system; genitourinary system; liver; and spleen. Orthologous to human RACK1 (receptor for activated C kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Rack1 |
| Official Name | receptor for activated C kinase 1 [Source:MGI Symbol;Acc:MGI:101849] |
| Ensembl ID | ENSMUSG00000020372 |
| Bio databases IDs | |
| Aliases | receptor for activated C kinase 1 |
| Synonyms | Activated Protein Kinase C Receptor, AL033335, D4Mgi39, epsilon RACK, GB-like, GNB2L1, GNB2-RS1, Guanine Binding Protein beta2 Rs1, Guanine nucleotide-binding protein subunit beta-2-like 1, Guanine nucleotide-binding protein subunit β-2-like 1, H12.3, HLC-7, p205, PIG21, receptor for activated C kinase 1, ε RACK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rack1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ion channel inhibitor
- signaling receptor activity
- SH2-domain binding
- protein phosphatase binding
- protein binding activity, bridging
- protein kinase C binding
- WD domain, G-beta repeat
- enzyme binding
- Pkc binding domain
- WD40
- protein domain specific binding
- enzyme
- caspase activator
- protein binding
- enzyme activator activity
- identical protein binding
- cyclin binding
- WD-like repeat
- protein serine/threonine kinase inhibitor
- WD40 repeats
- receptor tyrosine kinase binding
- protein tyrosine kinase inhibitor activity
- ribosome binding
- protein homodimerization
Pathways
Biological processes and signaling networks where the Rack1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- epithelial cancer
- cancer
- neoplasia
- hepatic fibrosis
- COVID-19
- liver cancer
- hepatocellular carcinoma
- renal clear cell adenocarcinoma
- non-small cell lung cancer
role in cell
- stabilization in
- expression in
- quantity
- transactivation in
- phosphorylation in
- activation in
- formation
- formation in
- binding in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosomal fraction
- cytoskeleton
- apical compartment
- perinuclear region
- cellular membrane
- focal adhesions
- ribosome
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- Mitochondria
- midbody
- cell-cell contacts
- granules
- cytosol
- apical membrane
- lateral plasma membrane
- nucleoplasm
- nuclear envelope
- neurites
- stress granule
- perikaryon
- dendrites
- phagocytic cups
- cytoskeletal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rack1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Golgi to plasma membrane protein transport
- cytoplasmic translation
- negative regulation of protein binding
- positive regulation of GTPase activity
- regulation of cell division
- cellular response to glucose stimulus
- rescue of stalled ribosome
- negative regulation of cell growth
- pigmentation
- apoptotic process
- negative regulation of peptidyl-serine phosphorylation
- positive regulation of mitochondrial depolarization
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- regulation of cell cycle
- positive regulation of intrinsic apoptotic signaling pathway
- negative regulation of translation
- positive regulation of protein complex assembly
- regulation of establishment of cell polarity
- regulation of protein localization
- negative regulation of endoplasmic reticulum unfolded protein response
- negative regulation of smoothened signaling pathway
- gastrulation
- negative regulation of gene expression
- rhythmic process
- cellular response to growth factor stimulus
- positive regulation of apoptotic process
- positive regulation of protein phosphorylation
- positive regulation of gastrulation
- negative regulation of Wnt receptor signaling pathway
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein ubiquitination
- positive regulation of cell migration
- negative regulation of phagocytosis
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- cytosolic small ribosomal subunit
- neuronal cell body
- perikaryon
- phagocytic cup
- nucleoplasm
- dendrite
- nucleus
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- cytoplasm
- mitochondrion
- cytosol
- small ribosomal subunit
- midbody
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- protein phosphatase binding
- protein homodimerization activity
- signaling adaptor activity
- protein tyrosine kinase inhibitor activity
- enzyme activator activity
- ion channel inhibitor activity
- SH2 domain binding
- receptor binding
- cysteine-type endopeptidase activator activity involved in apoptotic process
- BH3 domain binding
- translation regulator activity
- RNA binding
- protein binding
- cadherin binding
- ribosome binding
- cyclin binding
- receptor tyrosine kinase binding
- binding, bridging
- enzyme binding