Fchsd1 Gene Summary [Mouse]
Predicted to enable lipid binding activity. Involved in membrane organization and positive regulation of actin filament polymerization. Acts upstream of or within several processes, including import into nucleus; inflammatory response; and response to hydrogen peroxide. Part of protein-containing complex. Is active in cytosol. Colocalizes with cuticular plate. Orthologous to human FCHSD1 (FCH and double SH3 domains 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Fchsd1 |
| Official Name | FCH and double SH3 domains 1 [Source:MGI Symbol;Acc:MGI:2441771] |
| Ensembl ID | ENSMUSG00000038524 |
| Bio databases IDs | |
| Aliases | FCH and double SH3 domains 1 |
| Synonyms | A030002D08Rik, FCH and double SH3 domains 1, NWK2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fchsd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fes/CIP4, and EFC/F-BAR homology domain
- protein binding
- Bin/Amphiphysin/Rvs domain
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytosol
- stereocilia
- cuticular plate
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fchsd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of actin filament polymerization
- membrane organization
- neuromuscular synaptic transmission
- positive regulation of actin filament polymerization
Cellular Component
Where in the cell the gene product is active
- neuromuscular junction
- recycling endosome
- perikaryon
- cell projection
- cuticular plate
Molecular Function
What the gene product does at the molecular level
- lipid binding