Gabpb1 Gene Summary [Mouse]
Predicted to enable transcription cis-regulatory region binding activity. Involved in mitochondrion organization. Predicted to be located in cytoplasmic ribonucleoprotein granule and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and limb. Orthologous to human GABPB1 (GA binding protein transcription factor subunit beta 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gabpb1 |
| Official Name | GA repeat binding protein, beta 1 [Source:MGI Symbol;Acc:MGI:95611] |
| Ensembl ID | ENSMUSG00000027361 |
| Bio databases IDs | |
| Aliases | GA repeat binding protein, beta 1 |
| Synonyms | BABPB2, E4TF1, E4TF1-47, E4TF1-53, E4TF1B, Gabbp2, GA binding protein transcription factor subunit beta 1, GA binding protein transcription factor subunit β 1, Ga-binding protein transcription factor, β subunit 1 (53kd), GABPB, GABPB1-1, GABPB1-2, GABPB-2, GABP beta, GABP beta1, GABP β, Gabp γ, GA repeat binding protein, beta 1, GA repeat binding protein, β 1, Nrf2, Nrf2b, NRF2B1, NRF2B2, RGD1560391 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gabpb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- dimerization domain
- nucleic acid binding
- Ankyrin repeats (3 copies)
- transcription activation domain
- protein binding
- sequence-specific DNA binding
- Ankyrin repeat
- double-stranded DNA binding
- glutamine repeat domain
- Neh6 domain
- Mob-binding domain found in the NDR/LATS family serine/threonine protein kinases
- ankyrin repeats
Pathways
Biological processes and signaling networks where the Gabpb1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- epithelial cancer
- epithelial neoplasia
- osteoarthritis
- head and neck neoplasia
- small cell lung cancer
- tumorigenesis
- kidney injury
- lung carcinoma process
role in cell
- expression in
- proliferation
- activation in
- apoptosis
- migration
- induction in
- organization
- DNA damage response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- detergent resistant lipid raft fraction
- cytoplasmic ribonucleoprotein granule
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gabpb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription regulatory region sequence-specific DNA binding