Palld Gene Summary [Mouse]
Predicted to enable axon guidance receptor activity and cytoskeletal protein binding activity. Acts upstream of or within actin cytoskeleton organization; epithelial cell morphogenesis; and keratinocyte development. Located in Z disc; focal adhesion; and stress fiber. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; heart; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human PALLD (palladin, cytoskeletal associated protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Palld |
| Official Name | palladin, cytoskeletal associated protein [Source:MGI Symbol;Acc:MGI:1919583] |
| Ensembl ID | ENSMUSG00000058056 |
| Bio databases IDs | |
| Aliases | palladin, cytoskeletal associated protein |
| Synonyms | 2410003B16Rik, 6030492A02, AABR07025295.1, CGI-151, KIAA0992, LOC103693936, MYN, palladin, cytoskeletal associated protein, Palldl1, PNCA1, SIH002 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Palld often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoskeletal protein binding
- immunoglobulin domain
- actinin binding
- Immunoglobulin like
- alpha actinin binding domain
- Immunoglobulin I-set domain
- protein binding
- proline rich domain
- polyproline motif
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- acute myeloid leukemia
- idiopathic scoliosis
- autosomal dominant polycystic kidney disease
- breast carcinoma
- glioblastoma
- glioblastoma cancer
- metastasis
- colorectal cancer
- pancreatic carcinoma
role in cell
- apoptosis
- quantity
- phosphorylation in
- activation
- migration
- formation
- formation in
- morphology
- adhesion
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- axon component
- ruffle
- cytoskeleton
- Cytoplasm
- invadopodia
- focal adhesions
- podosomes
- actin cytoskeleton
- Nucleus
- Mitochondria
- actin filaments
- actin bundles
- cytosol
- growth cone
- intercalated disks
- Z line
- actin stress fibers
- filopodia
- cell membrane leading edge
- perikaryon
- axons
- excitatory synapses
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Palld gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- dendrite self-avoidance
- epithelial cell morphogenesis
- axon guidance
- homophilic cell adhesion
- cell migration
- actin cytoskeleton organization
- keratinocyte development
Cellular Component
Where in the cell the gene product is active
- excitatory synapse
- actin filament
- plasma membrane
- podosome
- growth cone
- Z disc
- nucleus
- focal adhesion
- stress fiber
- mitochondrion
- actin cytoskeleton
- ruffle
- cytosol
- axon
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- muscle alpha-actinin binding