Sbk1 Gene Summary [Mouse]
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in chromatin remodeling. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human SBK1 (SH3 domain binding kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sbk1 |
| Official Name | SH3-binding kinase 1 [Source:MGI Symbol;Acc:MGI:2135937] |
| Ensembl ID | ENSMUSG00000042978 |
| Bio databases IDs | |
| Aliases | SH3-binding kinase 1 |
| Synonyms | LOC103690016, LOC112868, SBK, SH3-binding domain kinase 1, SH3-binding kinase 1, SH3 domain binding kinase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sbk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- peptide
- L-threonine
disease
- systemic lupus erythematosus
- metabolic syndrome X
- pervasive developmental disorder
- lung adenocarcinoma
- lung adenocarcinoma formation
- acute myeloid leukemia
- inflammatory bowel disease
- allergy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sbk1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein serine/threonine kinase activity