Shoc1 Gene Summary [Mouse]
Predicted to enable ATP hydrolysis activity and single-stranded DNA binding activity. Involved in resolution of meiotic recombination intermediates and synaptonemal complex assembly. Located in condensed nuclear chromosome. Human ortholog(s) of this gene implicated in spermatogenic failure 75. Orthologous to human SHOC1 (shortage in chiasmata 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Shoc1 |
| Official Name | shortage in chiasmata 1 [Source:MGI Symbol;Acc:MGI:2140313] |
| Ensembl ID | ENSMUSG00000038598 |
| Bio databases IDs | |
| Aliases | shortage in chiasmata 1 |
| Synonyms | AABR07048387.1, C9orf84, Gm426, LOC682456, MZIP2, shortage in chiasmata 1, SPGF75, ZIP2, ZIP2H |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Shoc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA binding
- enzyme
- protein binding
- ATPase
- Family of unknown function (DUF5587)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Shoc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- reciprocal meiotic recombination
- synaptonemal complex assembly
- resolution of meiotic recombination intermediates
Cellular Component
Where in the cell the gene product is active
- chromosome
- condensed nuclear chromosome
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- single-stranded DNA binding