Ucn Gene Summary [Mouse]
This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. Mice lacking the encoded protein exhibit a heightened anxiety-like behaviors and a significantly reduced acoustic startle response. [provided by RefSeq, Sep 2016]
Details
| Type | Protein Coding |
| Official Symbol | Ucn |
| Official Name | urocortin [Source:MGI Symbol;Acc:MGI:1276123] |
| Ensembl ID | ENSMUSG00000038676 |
| Bio databases IDs | |
| Aliases | urocortin |
| Synonyms | Mpv17, UCN1, UI, UROC, urocortin, UROCORTIN I, UROTENSIN I |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ucn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Corticotropin-releasing factor family
- G-protein-coupled receptor binding
- histone deacetylase inhibitor activity
- protein binding
- receptor binding
- neuropeptide hormone
Pathways
Biological processes and signaling networks where the Ucn gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- hypotension
- endometriosis
- tachycardia
- colon adenocarcinoma
- colon epithelial cancer
- collagen-induced arthritis
- gastroparesis
role in cell
- proliferation
- cell death
- apoptosis
- migration
- growth
- production in
- expression in
- phosphorylation in
- differentiation
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- axon component
- cell surface
- perikaryon
- axons
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ucn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- drinking behavior
- positive regulation of translation
- negative regulation of appetite
- positive regulation of DNA replication
- vasodilation
- associative learning
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of neuron apoptotic process
- response to pain
- sensory perception of sound
- response to oxidative stress
- positive regulation of cell growth
- positive regulation of collagen biosynthetic process
- startle response
- response to glucocorticoid stimulus
- positive regulation of corticotropin secretion
- negative regulation of cell size
- response to auditory stimulus
- regulation of synaptic transmission, glutamatergic
- positive regulation of peptidyl-serine phosphorylation
- social behavior
- positive regulation of cardiac muscle contraction
- negative regulation of feeding behavior
- G-protein coupled receptor signaling pathway
- neuron projection development
- female pregnancy
- negative regulation of blood pressure
- positive regulation of cAMP-mediated signaling
- negative regulation of hormone secretion
- positive regulation of vascular permeability
- positive regulation of calcium ion import
- negative regulation of gene expression
- neuropeptide signaling pathway
- positive regulation of behavioral fear response
- response to estradiol stimulus
- positive regulation of interleukin-6 production
- aerobic respiration
Cellular Component
Where in the cell the gene product is active
- dendrite
- varicosity
- extracellular region
- perikaryon
- axon terminus
Molecular Function
What the gene product does at the molecular level
- corticotropin-releasing hormone receptor 2 binding
- protein binding
- corticotropin-releasing hormone receptor 1 binding
- neuropeptide hormone activity
- histone deacetylase inhibitor activity