Crhr1 Gene Summary [Mouse]
The protein encoded by this gene is a G-protein coupled receptor that binds corticotropin-releasing factor (CRH) and urocortin (UCN) with high affinity. The encoded protein upregulates adenylate cyclase activity and intracellular cAMP levels. This protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response, and obesity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | Crhr1 |
| Official Name | corticotropin releasing hormone receptor 1 [Source:MGI Symbol;Acc:MGI:88498] |
| Ensembl ID | ENSMUSG00000018634 |
| Bio databases IDs | |
| Aliases | corticotropin releasing hormone receptor 1 |
| Synonyms | CORTICOTROPHIN RELEASING FACTOR1 receptor, corticotropin releasing hormone receptor 1, CRF1, CRF1R, CRF-R, CRF-R-1, CRF-R1alpha, Crfr type 1, CRH-R, CRHR1L, LOC100131650 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crhr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- 7 transmembrane receptor (Secretin family)
- extracellular domain
- peptide binding
- intracellular loop
- signaling receptor activity
- Class I PDZ binding motif
- signal peptide
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
- binding protein
- transmembrane domain
- tail domain
- corticotrophin-releasing factor receptor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Crhr1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- neurodegeneration
- COVID-19
- withdrawal syndrome
- hypoplasia
- obesity
- neuroticism
- depressive disorder
- anorexia
- pulmonary emphysema
role in cell
- expression in
- apoptosis
- activation in
- production in
- proliferation
- elevation in
- binding
- accumulation in
- formation in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- cell surface
- intracellular space
- apical compartment
- cellular membrane
- Nucleus
- vesicles
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- synaptic membrane
- trans Golgi network
- multivesicular bodies
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crhr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- exploration behavior
- female pregnancy
- fear response
- cell surface receptor signaling pathway
- behavioral response to ethanol
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- parturition
- immune response
- cellular response to corticotropin-releasing hormone stimulus
- regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
- regulation of corticosterone secretion
- activation of adenylate cyclase activity
- general adaptation syndrome, behavioral process
- adrenal gland development
- corticotropin secretion
Cellular Component
Where in the cell the gene product is active
- endosome
- membrane
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled peptide receptor activity
- protein binding
- corticotrophin-releasing factor receptor activity
- corticotropin-releasing hormone binding
- corticotropin-releasing hormone receptor activity