Rln1 Gene Summary [Mouse]
Enables signaling receptor binding activity. Involved in mammary gland development; regulation of apoptotic process; and spermatogenesis. Acts upstream of or within prostate gland growth and regulation of nitric oxide mediated signal transduction. Predicted to be located in extracellular region. Is expressed in several structures, including Harderian gland; alimentary system; genitourinary system; immune system; and liver and biliary system. Orthologous to several human genes including RLN2 (relaxin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Rln1 |
| Official Name | relaxin 1 [Source:MGI Symbol;Acc:MGI:97931] |
| Ensembl ID | ENSMUSG00000039097 |
| Bio databases IDs | |
| Aliases | relaxin 1 |
| Synonyms | relaxin 1, Rln, rlx |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rln1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- receptor binding
Pathways
Biological processes and signaling networks where the Rln1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
disease
- dystocia
- oligozoospermia
phenotypes
- abnormal epididymis morphology
- abnormal involution of the mammary gland
- abnormal male reproductive system morphology
- abnormal mammary gland duct morphology
- abnormal mammary gland growth during lactation
- abnormal mammary gland growth during pregnancy
- abnormal nipple morphology
- abnormal prostate gland development
- abnormal prostate gland epithelium morphology
- abnormal prostate gland morphology
- abnormal pubic symphysis morphology
- abnormal seminiferous tubule morphology
- abnormal spermatogenesis
- abnormal suckling behavior
- abnormal testis morphology
- absent gastric milk in neonates
- decreased body size
- decreased body weight
- decreased nipple size
- delayed sexual maturation
- dystocia
- increased apoptosis
- increased blood osmolality
- neonatal lethality
- oligozoospermia
- reduced male fertility
- small epididymis
- small prostate gland
- small seminal vesicle
- small testis
role in cell
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space