Has2 Gene Summary [Mouse]
Enables hyaluronan synthase activity. Involved in several processes, including circulatory system development; extracellular matrix assembly; and hyaluronan biosynthetic process. Acts upstream of or within bone morphogenesis and hyaluronan metabolic process. Located in cytoplasmic vesicle and plasma membrane raft. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; heart; and skin. Orthologous to human HAS2 (hyaluronan synthase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Has2 |
| Official Name | hyaluronan synthase 2 [Source:MGI Symbol;Acc:MGI:107821] |
| Ensembl ID | ENSMUSG00000022367 |
| Bio databases IDs | |
| Aliases | hyaluronan synthase 2 |
| Synonyms | hyaluronan synthase 2, Hyaluronan synthase homolog |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Has2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl transferase family 2
- hyaluronan synthase
- enzyme
- protein binding
- Glycosyltransferase like family 2
- identical protein binding
- glycosyltransferase family A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- oral squamous cell carcinoma
- early missed abortion
- tumorigenesis
- fibrosis
- airway inflammation
- diabetic nephropathy
- congenital heart disease
- airway hyperresponsiveness
- Graves ophthalmopathy
- growth failure
role in cell
- expression in
- production in
- density
- quantity
- growth
- phosphorylation in
- apoptosis
- proliferation
- invasion by
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- extracellular vesicles
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- endoplasmic reticulum membrane
- cytoplasmic vesicles
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Has2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to platelet-derived growth factor stimulus
- positive regulation of cell proliferation
- bone morphogenesis
- extracellular polysaccharide biosynthetic process
- extracellular matrix assembly
- vasculogenesis
- positive regulation of substrate adhesion-dependent cell spreading
- positive regulation of hyaluronan biosynthetic process
- positive regulation of monocyte aggregation
- renal water absorption
- positive regulation of keratinocyte proliferation
- cellular response to fluid shear stress
- kidney development
- cellular response to interleukin-1
- cellular response to tumor necrosis factor
- positive regulation of keratinocyte migration
- positive regulation of smooth muscle cell migration
- hyaluronan biosynthetic process
- positive regulation of urine volume
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasmic vesicle
- Golgi membrane
- Golgi apparatus
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- hyaluronan synthase activity