Megf9 Gene Summary [Mouse]
Predicted to be involved in several processes, including axon guidance; basement membrane assembly; and substrate adhesion-dependent cell spreading. Located in basement membrane. Is expressed in several structures, including eye; gut epithelium; nervous system; olfactory epithelium; and skin. Orthologous to human MEGF9 (multiple EGF like domains 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Megf9 |
| Official Name | multiple EGF-like-domains 9 [Source:MGI Symbol;Acc:MGI:1918264] |
| Ensembl ID | ENSMUSG00000039270 |
| Bio databases IDs | |
| Aliases | multiple EGF-like-domains 9 |
| Synonyms | 4933405H16Rik, 9630025C07, EGFL5, mKIAA0818, multiple EGF-like-domains 9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Megf9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Laminin-type epidermal growth factor-like domai
- Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins
- EGF_CA
- Laminin EGF domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine leiomyoma
- leiomyomatosis
- acute myeloid leukemia
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- chronic central serous chorioretinopathy
- lung carcinoma
- lung carcinoma process
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Megf9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of actin filament polymerization
Cellular Component
Where in the cell the gene product is active
- basement membrane
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- small GTPase binding