Myh8 Gene Summary [Mouse]
This gene encodes a myosin heavy chain. The encoded protein forms a hexamer with two heavy chains, two alkali light chains, and two regulatory light chain components. This complex functions in muscle contraction. This gene is located in a cluster of related genes on chromosome 11. [provided by RefSeq, Jun 2013]
Details
| Type | Protein Coding |
| Official Symbol | Myh8 |
| Official Name | myosin, heavy polypeptide 8, skeletal muscle, perinatal [Source:MGI Symbol;Acc:MGI:1339712] |
| Ensembl ID | ENSMUSG00000055775 |
| Bio databases IDs | |
| Aliases | myosin, heavy polypeptide 8, skeletal muscle, perinatal |
| Synonyms | 4832426G23RIK, DA7, gtMHC-F, Mhc neonatal type, Mhc of neonatal type, MHCp, Mhc-perinatal, MyHC-peri, MyHC-pn, Myhs-p, myosin heavy chain 8, myosin, heavy polypeptide 8, skeletal muscle, perinatal, Neomyhc |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myh8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Autophagy protein 16 (ATG16)
- myosin phosphatase
- Synaptonemal complex protein 1 (SCP-1)
- ATP binding
- microfilament motor protein
- Myosin N-terminal SH3-like domain
- helix-rich Mycoplasma protein
- enzyme
- ATPase
- Laminin Domain I
- chromosome segregation protein SMC, common bacterial type
- myosin binding
- Tropomyosin
- HOOK protein coiled-coil region
- Mitotic checkpoint protein
- Crescentin protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Weak chloroplast movement under blue light
- PspA/IM30 family
- Myosin and Kinesin motor domain
- Domain of unknown function (DUF4618)
- rad50
- Myosin tail
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Myosin head (motor domain)
- Alpha helical coiled-coil rod protein (HCR)
- actin filament binding
- RecF/RecN/SMC N terminal domain
- RIM-binding protein of the cytomatrix active zone
- Coiled-coil domain-containing protein 158
- Intermediate filament protein
- Septation ring formation regulator, EzrA
- Myosin
Pathways
Biological processes and signaling networks where the Myh8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell cancer
- papillomatosis
- hecht syndrome
- Down syndrome
- facioscapulohumeral muscular dystrophy
- amyotrophic lateral sclerosis
- Carney complex variant
- venous thromboembolism
- papilloma
- squamous-cell carcinoma
regulates
- adenosine triphosphate
role in cell
- differentiation
- sliding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- myofibrils
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myh8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal muscle contraction
- muscle contraction
- ATP metabolic process
- muscle filament sliding
Cellular Component
Where in the cell the gene product is active
- muscle myosin complex
- cytoplasm
- myosin II complex
- myosin filament
- cytosol
- sarcomere
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- actin filament binding
- ATP binding
- calmodulin binding
- structural constituent of muscle
- myosin light chain binding
- microfilament motor activity
- myosin phosphatase activity