Dyrk1a Gene Summary [Mouse]
Enables identical protein binding activity; protein serine/threonine kinase activity; and tau protein binding activity. Involved in several processes, including negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of microtubule polymerization; and protein phosphorylation. Acts upstream of or within negative regulation of mRNA splicing, via spliceosome and peptidyl-tyrosine phosphorylation. Located in several cellular components, including axon; cytoskeleton; and dendrite. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and sensory organ. Used to study Down syndrome and autosomal dominant intellectual developmental disorder 7. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant intellectual developmental disorder 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dyrk1a |
| Official Name | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a [Source:MGI Symbol;Acc:MGI:1330299] |
| Ensembl ID | ENSMUSG00000022897 |
| Bio databases IDs | |
| Aliases | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a |
| Synonyms | 2310043O08Rik, D16Ertd272e, D16Ertd493e, dual specificity tyrosine phosphorylation regulated kinase 1A, DYRK, DYRK1, Gm10783, HP86, mmb, MNB, MNBH, Mp86, MRD7, PSK47 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dyrk1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- DYRK homology box
- [RNA-polymerase]-subunit kinase
- protein threonine/tyrosine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- catalytic domain
- non-membrane spanning protein tyrosine kinase
- enzyme
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- identical protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- cytoskeletal protein binding
- Protein Kinases, catalytic domain
- tau protein binding
- tubulin binding
- actin binding
- alcohol group acceptor phosphotransferase
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Dyrk1a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- human immunodeficiency virus I infection
- rectum cancer
- impaired glucose tolerance
- insulin resistance
- autosomal dominant mental retardation type 7
- Alzheimer disease
- complex neurodevelopmental disorder
- metabolic syndrome X
- hereditary disorder
- postmenopausal osteoporosis
role in cell
- proliferation
- cell death
- activation in
- number
- quantity
- induction in
- oligomerization in
- replication in
- cell viability
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- axon-like process
- cytoskeleton
- Cytoplasm
- perinuclear region
- centrosome
- microtubules
- actin filaments
- cytosol
- nucleoplasm
- nuclear speckles
- neurofilaments
- perikaryon
- axons
- dendrites
- presynaptic terminals
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dyrk1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- negative regulation of DNA damage response, signal transduction by p53 class mediator
- positive regulation of protein deacetylation
- positive regulation of RNA splicing
- negative regulation of methylation-dependent chromatin silencing
- nervous system development
- peptidyl-tyrosine autophosphorylation
- protein autophosphorylation
- circadian rhythm
- protein phosphorylation
- regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- negative regulation of nuclear mRNA splicing, via spliceosome
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- negative regulation of microtubule polymerization
- beta-amyloid formation
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- cytoskeleton
- cytoplasm
- nuclear speck
- axon
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- RNA polymerase II carboxy-terminal domain kinase activity
- protein kinase activity
- protein serine/threonine kinase activity
- tau-protein kinase activity
- ATP binding
- protein tyrosine kinase activity
- protein binding
- protein serine/threonine/tyrosine kinase activity
- non-membrane spanning protein tyrosine kinase activity
- transcription coactivator activity
- tau protein binding