Mpp1 Gene Summary [Mouse]
This gene encodes a protein localized to the cell membrane. The protein serves as a scaffold for the assembly of the actin cytoskeleton, and plays a role in regulating apico-basal cell polarity. [provided by RefSeq, May 2015]
Details
| Type | Protein Coding |
| Official Symbol | Mpp1 |
| Official Name | membrane protein, palmitoylated [Source:MGI Symbol;Acc:MGI:105941] |
| Ensembl ID | ENSMUSG00000031402 |
| Bio databases IDs | |
| Aliases | membrane protein, palmitoylated |
| Synonyms | AAG12, C130070C03Rik, DXS552E, EM55, EMP55, MAGUK p55 scaffold protein 1, membrane protein, palmitoylated, MRG1, p55, PEMP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mpp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- guanylate kinase
- ERM binding domain
- Domain present in PSD-95, Dlg, and ZO-1/2
- NK
- canonical PDZ domain
- protein binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
- tyrosine phosphorylation site
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sickle cell anemia
- Turner syndrome
- renal cell carcinoma
- renal cell cancer
- Waldenström macroglobulinemia
regulates
- AKT
- phosphatidylinositol-3,4,5-triphosphate
role in cell
- phosphorylation in
- formation
- formation in
- function
- number
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- kinocilia
- cortical cytoskeleton
- cellular membrane
- Nucleus
- centrosome
- stereocilia
- apical cell surfaces
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mpp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- GDP metabolic process
- regulation of neutrophil chemotaxis
- GMP metabolic process
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- centriolar satellite
- membrane
- stereocilium
- plasma membrane
- cortical cytoskeleton
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanylate kinase activity
- receptor binding