Tcaf2 Gene Summary [Mouse]
Predicted to enable transmembrane transporter binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in cell junction. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; limb; nervous system; sensory organ; and urinary system. Orthologous to several human genes including TCAF2 (TRPM8 channel associated factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tcaf2 |
| Official Name | TRPM8 channel-associated factor 2 [Source:MGI Symbol;Acc:MGI:2385258] |
| Ensembl ID | ENSMUSG00000029851 |
| Bio databases IDs | |
| Aliases | TRPM8 channel-associated factor 2 |
| Synonyms | AC275440.2, FAM115C, FAM139A, FLJ40722, GATD9, GATD9B, LOC101928422, LOC101930379, LOC103689990, RGD1304806, Tcaf2c, TRPM8 channel-associated factor 2, TRPM8 channel associated factor 2C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tcaf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-terminal domain of M60-like peptidases
- Peptidase M60, enhancin and enhancin-like
- ion channel binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tcaf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of anion channel activity
- positive regulation of protein targeting to membrane
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cell junction
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ion channel binding