Nrtn Gene Summary [Mouse]
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. Homozygous knockout mice for this gene exhibit defects in the development of the retina and enteric nervous system, and reduced cholinergic innervation of the heart and lacrimal glands. [provided by RefSeq, Aug 2016]
Details
| Type | Protein Coding |
| Official Symbol | Nrtn |
| Official Name | neurturin [Source:MGI Symbol;Acc:MGI:108417] |
| Ensembl ID | ENSMUSG00000039481 |
| Bio databases IDs | |
| Aliases | neurturin |
| Synonyms | neurturin, NTN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nrtn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- TGF_beta_SF
- Transforming growth factor beta like domain
- receptor binding
- growth factor
- glycosaminoglycan binding
Pathways
Biological processes and signaling networks where the Nrtn gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- keratoconjunctivitis sicca
- hypoperistalsis
- enophthalmos
- heat hyperalgesia
- parkinsonism
- dry eye
- ptosis
- airway hyperresponsiveness
regulated by
- Ca2+
- heavy metal
- dexamethasone
- lipopolysaccharide
- beta-estradiol
- MMP1
- NOS2
- MIR3648
- quinolinic acid
- SH-SY5Y cells
role in cell
- apoptosis
- damage
- quantity
- activation in
- phosphorylation in
- cell death
- production in
- differentiation
- size
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nrtn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- glial cell-derived neurotrophic factor receptor signaling pathway
- neural crest cell migration
- neuron projection development
- nervous system development
- transmembrane receptor protein tyrosine kinase signaling pathway
- nerve development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
- axon
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- receptor tyrosine kinase binding
- receptor binding
- glial cell line-derived neurotrophic factor receptor binding