Mocos Gene Summary [Mouse]
Predicted to enable molybdenum cofactor sulfurtransferase activity. Involved in molybdopterin cofactor biosynthetic process. Is expressed in naris and olfactory epithelium. Used to study obstructive nephropathy and xanthinuria type II. Human ortholog(s) of this gene implicated in xanthinuria type II. Orthologous to human MOCOS (molybdenum cofactor sulfurase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mocos |
| Official Name | molybdenum cofactor sulfurase [Source:MGI Symbol;Acc:MGI:1915841] |
| Ensembl ID | ENSMUSG00000039616 |
| Bio databases IDs | |
| Aliases | molybdenum cofactor sulfurase |
| Synonyms | 1110018O12Rik, HMCS, MCS, molybdenum cofactor sulfurase, molybdenum cofactor sulphurase, MOS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mocos often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aminotransferase class-V
- Mo-molybdopterin cofactor sulfurase
- MOSC domain
- MOSC N-terminal beta barrel domain
- AAT_I
- enzyme
- protein binding
- molybdenum cofactor sulfurtransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mocos gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- molybdopterin cofactor metabolic process
- Mo-molybdopterin cofactor biosynthetic process
- molybdopterin cofactor biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- protein binding
- Mo-molybdopterin cofactor sulfurase activity
- molybdenum ion binding
- lyase activity