Crtac1 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity. Involved in regulation of synapse assembly. Acts upstream of or within axonal fasciculation and olfactory bulb development. Located in growth cone. Is active in glutamatergic synapse and postsynaptic density. Is expressed in central nervous system; dorsal root ganglion; semicircular canal epithelium; tooth; and vibrissa. Orthologous to human CRTAC1 (cartilage acidic protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crtac1 |
| Official Name | cartilage acidic protein 1 [Source:MGI Symbol;Acc:MGI:1920082] |
| Ensembl ID | ENSMUSG00000042401 |
| Bio databases IDs | |
| Aliases | cartilage acidic protein 1 |
| Synonyms | 2810454P21Rik, ASPIC, ASPIC1, AW047536, cartilage acidic protein 1, CEP-68, Crtac1B, LOTUS, W307 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crtac1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- ASPIC and UnbV
- FG-GAP-like repeat
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- microgliosis
- metabolic syndrome X
- idiopathic pulmonary fibrosis
- nicotine dependence
- amyotrophic lateral sclerosis
- astrocytosis
- ischemic stroke
- lung carcinoma
role in cell
- expression in
- binding in
- apoptosis
- density
- degradation in
- cisplatin sensitivity
- innervation in
- dephosphorylation in
- elimination in
- elimination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- growth cone
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crtac1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- axonal fasciculation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding