Pdcd6ip Gene Summary [Mouse]
Enables identical protein binding activity and protein dimerization activity. Involved in several processes, including actomyosin contractile ring assembly; bicellular tight junction assembly; and maintenance of epithelial cell apical/basal polarity. Located in actomyosin; cytosol; and extracellular exosome. Is expressed in several structures, including branchial arch; facial prominence; gut; limb bud; and neural fold. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 29. Orthologous to human PDCD6IP (programmed cell death 6 interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdcd6ip |
| Official Name | programmed cell death 6 interacting protein [Source:MGI Symbol;Acc:MGI:1333753] |
| Ensembl ID | ENSMUSG00000032504 |
| Bio databases IDs | |
| Aliases | programmed cell death 6 interacting protein |
| Synonyms | AIP, AIP1, ALIX, DRIP4, Eig2, HP95, MCPH29, mKIAA1375, programmed cell death 6 interacting protein, RGD1561176 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pdcd6ip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tsg101 binding domain
- protein dimerization
- PXY motif
- Protein-interacting V-domain of mammalian Alix and related domains
- calcium-dependent protein binding
- BRO1/Rhophilin-like domain
- ALIX V-shaped domain binding to HIV
- polar amino acid rich domain
- G-protein-coupled receptor binding
- coiled-coil domain
- PSAP motif
- protein binding
- V domain
- identical protein binding
- proline rich domain
- SH3-domain binding
- Protein-interacting Bro1-like domain of mammalian Alix and related domains
- BRO1-like domain
- GPP motif
- protein homodimerization
- endophilin binding domain
- CIN85-binding motif
- CHMP4b binding site
Pathways
Biological processes and signaling networks where the Pdcd6ip gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive primary microcephaly type 29
- hydrocephalus
- astrocytosis
- renal cancer
- infection by HIV-1
role in cell
- expression in
- apoptosis
- binding in
- production in
- replication in
- morphology
- cell death
- degradation in
- formation
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- membrane fraction
- detergent resistant lipid raft fraction
- cell surface
- cell periphery
- perinuclear region
- cellular membrane
- actin cytoskeleton
- Plasma Membrane
- endosomes
- vesicles
- centrosome
- Endoplasmic Reticulum
- midbody
- immunological synapses
- Flemming body
- cytosol
- neurites
- late endosomes
- multivesicular bodies
- filopodia
- perikaryon
- exosomes
- phagosomes
- lamellipodia
- cytoskeletal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pdcd6ip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytokinesis, actomyosin contractile ring assembly
- protein transport
- protein homooligomerization
- non-lytic virus budding
- nucleus organization
- maintenance of epithelial cell apical/basal polarity
- regulation of centrosome duplication
- cytokinesis after mitosis
- apoptotic process
- tight junction assembly
- multivesicular body sorting pathway
- mitotic metaphase plate congression
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- tight junction
- centrosome
- extracellular vesicular exosome
- endosome
- focal adhesion
- melanosome
- membrane
- cytosol
- endoplasmic reticulum exit site
- actomyosin
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- proteinase activated receptor binding
- calcium-dependent protein binding