Nup43 Gene Summary [Mouse]
Predicted to be involved in nucleocytoplasmic transport. Predicted to be located in cytosol; nuclear envelope; and nuclear speck. Predicted to be part of nuclear pore outer ring. Predicted to colocalize with kinetochore. Is expressed in several structures, including gut; lung; olfactory epithelium; tooth; and urinary system. Orthologous to human NUP43 (nucleoporin 43). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nup43 |
| Official Name | nucleoporin 43 [Source:MGI Symbol;Acc:MGI:1917162] |
| Ensembl ID | ENSMUSG00000040034 |
| Bio databases IDs | |
| Aliases | nucleoporin 43 |
| Synonyms | 2610016K01RIK, 2610529I12RIK, bA350J20.1, FLJ13287, nucleoporin 43, p42 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nup43 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- protein binding
- transporter
Pathways
Biological processes and signaling networks where the Nup43 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- metaphase plate
- cytosol
- nuclear pores
- nucleoplasm
- nuclear rim
- nuclear envelope
- nuclear speckles
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nup43 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- nucleocytoplasmic transport
- protein transport
- chromosome segregation
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- Nup107-160 complex
- nuclear speck
- cytosol
- kinetochore
- nuclear pore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding