Ckap2l Gene Summary [Mouse]
Predicted to be located in microtubule cytoskeleton. Predicted to be active in centrosome; cytosol; and mitotic spindle. Is expressed in brain ventricular layer; forebrain; nephrogenic zone; and thymus primordium. Human ortholog(s) of this gene implicated in Filippi syndrome. Orthologous to human CKAP2L (cytoskeleton associated protein 2 like). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ckap2l |
| Official Name | cytoskeleton associated protein 2-like [Source:MGI Symbol;Acc:MGI:1917716] |
| Ensembl ID | ENSMUSG00000048327 |
| Bio databases IDs | |
| Aliases | cytoskeleton associated protein 2-like |
| Synonyms | 2010016H04Rik, 2610318C08Rik, cytoskeleton associated protein 2-like, FLJ40629, LOC688100, radmis, rdm |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ckap2l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cytoskeleton-associated protein 2 C-terminus
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Filippi syndrome
- colorectal cancer
- acute myeloid leukemia
- lung adenocarcinoma
- lung adenocarcinoma formation
- chronic lymphocytic leukemia
- dysmenorrhea
- chronic myeloid leukemia
role in cell
- proliferation
- expression in
- cell death
- growth
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- cilia
- Nucleus
- centrosome
- cytosol
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ckap2l gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- centrosome
- mitotic spindle
- spindle pole
- cytosol