Elf1 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of T cell receptor signaling pathway and regulation of cytokine production. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ELF1 (E74 like ETS transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Elf1 |
| Official Name | E74-like factor 1 [Source:MGI Symbol;Acc:MGI:107180] |
| Ensembl ID | ENSMUSG00000036461 |
| Bio databases IDs | |
| Aliases | E74-like factor 1 |
| Synonyms | E74 like ETS transcription factor 1, EFTUD1, mElf-1, p70, RIA1, Sts1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Elf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- DNA binding domain
- nucleic acid binding
- double-stranded DNA binding
- Ets-domain
- protein binding
- sequence-specific DNA binding
- transcription factor activity
- Transcription factor protein N terminal
Pathways
Biological processes and signaling networks where the Elf1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- systemic lupus erythematosus
- inflammatory bowel disease
- COVID-19
- clonal hematopoiesis
- experimental autoimmune encephalomyelitis
- Crohn disease
- ulcerative colitis
regulated by
- doxorubicin
- lipopolysaccharide
- epigallocatechin-gallate
- methamphetamine
- beta-estradiol
- okadaic acid
- E. coli B4 lipopolysaccharide
- macrophages
- trichostatin A
- PP2A
role in cell
- survival
- production in
- growth
- expression in
- quantity
- proliferation
- function
- differentiation
- transactivation in
- selection
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Elf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of T cell receptor signaling pathway
- positive regulation of transcription, DNA-dependent
- cell differentiation
- regulation of cytokine production
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity