Cuzd1 Gene Summary [Mouse]
Involved in trypsinogen activation. Located in zymogen granule membrane. Orthologous to human CUZD1 (CUB and zona pellucida like domains 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cuzd1 |
| Official Name | CUB and zona pellucida-like domains 1 [Source:MGI Symbol;Acc:MGI:1202881] |
| Ensembl ID | ENSMUSG00000040205 |
| Bio databases IDs | |
| Aliases | CUB and zona pellucida-like domains 1 |
| Synonyms | CUB and zona pellucida-like domains 1, ERG-1, ITMAP1, Uo, UO-44, Usg, Utczp |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cuzd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CUB
- Zona pellucida-like domain
- Zona pellucida (ZP) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- epithelial cancer
- epithelial neoplasia
- migraines
- pancreatitis
regulated by
- beta-estradiol
- tamoxifen
- growth hormone
- fulvestrant
role in cell
- growth
- expression in
- phosphorylation in
- proliferation
- morphology
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- cytosol
- zymogen granules
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cuzd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- trypsinogen activation
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- zymogen granule membrane
- cell surface