Ereg Gene Summary [Mouse]
Enables epidermal growth factor receptor binding activity; receptor ligand activity; and transmembrane receptor protein tyrosine kinase activator activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; positive regulation of macromolecule metabolic process; and positive regulation of mitotic nuclear division. Located in extracellular space. Is expressed in several structures, including extraembryonic component; heart; lung; ovary; and skin. Human ortholog(s) of this gene implicated in extrapulmonary tuberculosis; pulmonary tuberculosis; and tuberculosis. Orthologous to human EREG (epiregulin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ereg |
| Official Name | epiregulin [Source:MGI Symbol;Acc:MGI:107508] |
| Ensembl ID | ENSMUSG00000029377 |
| Bio databases IDs | |
| Aliases | epiregulin |
| Synonyms | Ep, Epiregulin, EPR, ER |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ereg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transmembrane receptor protein tyrosine kinase activator
- epidermal growth factor receptor binding
- ectodomain
- receptor agonist activity
- protein binding
- growth factor
Pathways
Biological processes and signaling networks where the Ereg gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- oral squamous cell carcinoma
- weight loss
- tumorigenesis
- organismal death
- breast cancer
- gout
- colorectal cancer
- dextran sodium sulfate-induced colitis
- squamous cell cancer of the oral cavity
- colitis
role in cell
- proliferation
- expression in
- cell viability
- apoptosis
- phosphorylation in
- growth
- migration
- colony formation
- maturation
- osimertinib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endocytic vesicle membrane
- cell surface
- cellular membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ereg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ERBB2-ERBB4 signaling pathway
- ERBB4-ERBB4 signaling pathway
- mRNA transcription
- ERBB2-EGFR signaling pathway
- epidermal growth factor receptor signaling pathway
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- negative regulation of smooth muscle cell differentiation
- positive regulation of DNA replication
- anatomical structure morphogenesis
- positive regulation of mitosis
- ovarian cumulus expansion
- positive regulation of smooth muscle cell proliferation
- wound healing
- positive regulation of cell division
- negative regulation of transcription, DNA-dependent
- angiogenesis
- positive regulation of fibroblast proliferation
- cytokine-mediated signaling pathway
- ovulation
- primary follicle stage
- positive regulation of phosphorylation
- keratinocyte proliferation
- female meiosis
- cell-cell signaling
- response to peptide hormone stimulus
- luteinizing hormone signaling pathway
- organ morphogenesis
- keratinocyte differentiation
- oocyte maturation
- positive regulation of innate immune response
- positive regulation of protein kinase activity
- negative regulation of epithelial cell proliferation
- positive regulation of interleukin-6 production
- positive regulation of cytokine production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- clathrin-coated endocytic vesicle membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- transmembrane receptor protein tyrosine kinase activator activity
- epidermal growth factor receptor binding
- receptor agonist activity