Gas8 Gene Summary [Mouse]
Enables microtubule binding activity and small GTPase binding activity. Involved in flagellated sperm motility; positive regulation of protein localization to cilium; and positive regulation of smoothened signaling pathway. Acts upstream of or within several processes, including axoneme assembly; determination of left/right symmetry; and epithelial cilium movement involved in extracellular fluid movement. Located in several cellular components, including ciliary basal body; glial cell projection; and sperm flagellum. Is expressed in bronchus; nasal cavity epithelium; and nervous system. Used to study primary ciliary dyskinesia 33. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 33. Orthologous to human GAS8 (growth arrest specific 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gas8 |
| Official Name | growth arrest specific 8 [Source:MGI Symbol;Acc:MGI:1202386] |
| Ensembl ID | ENSMUSG00000040220 |
| Bio databases IDs | |
| Aliases | growth arrest specific 8 |
| Synonyms | CILD33, DRC4, GAS11, growth arrest specific 8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gas8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- enzyme binding
- Growth-arrest specific micro-tubule binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell cancer
- epithelial cancer
- cancer
- hepatocellular carcinoma
- liver cancer
- primary ciliary dyskinesia type 33
- epithelial basal cell carcinoma
- melanoma
- melanoma cancer
- non-melanoma skin cancer
regulates
- SMO dimer
role in cell
- proliferation
- binding
- assembly
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- microtubule cytoskeleton
- intracellular membrane-bounded organelle
- cilia
- Plasma Membrane
- basal bodies
- Golgi Apparatus
- flagella
- microtubules
- axonemes
- cytosol
- sperm tail
- glial cell projections
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gas8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm motility
- cilium movement involved in cell motility
- negative regulation of cell proliferation
- positive regulation of smoothened signaling pathway
- protein localization
- epithelial cilium movement
- axoneme assembly
- establishment of localization in cell
- brain development
- determination of left/right symmetry
Cellular Component
Where in the cell the gene product is active
- motile cilium
- cilium basal body
- cilium
- cytosol
- Golgi apparatus
- sperm flagellum
- extracellular region
- axoneme
- plasma membrane
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding
- microtubule binding