Pcm1 Gene Summary [Mouse]
Predicted to enable molecular adaptor activity. Involved in several processes, including interkinetic nuclear migration; microtubule anchoring; and protein localization to centrosome. Acts upstream of or within several processes, including microtubule anchoring at centrosome; neuronal stem cell population maintenance; and social behavior. Located in apical part of cell; cytoplasm; and microtubule organizing center. Colocalizes with centrosome. Is expressed in brain; cardiac muscle tissue; and cerebral cortex ventricular layer. Orthologous to human PCM1 (pericentriolar material 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Pcm1 |
| Official Name | pericentriolar material 1 [Source:MGI Symbol;Acc:MGI:1277958] |
| Ensembl ID | ENSMUSG00000031592 |
| Bio databases IDs | |
| Aliases | pericentriolar material 1 |
| Synonyms | 2600002H09Rik, 9430077F19Rik, C030044G17Rik, LOC100044052, pericentriolar material 1, PTC4, RET/PCM-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pcm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- matrix binding domain
- Pericentriolar material 1 C terminus
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- cleft palate
- breast carcinoma
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- atrial fibrillation
- polycystic ovary syndrome
role in cell
- migration
- cell cycle progression
- assembly
- senescence
- cycling
- formation
- interaction in
- mitosis
- replication
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- ciliary transition zone
- pericentriolar matrix
- heterochromatin
- centriolar satellite
- cilia
- apical compartment
- basal bodies
- centrosome
- centriole
- granules
- cytosol
- nuclear foci
- nucleoplasm
- nuclear envelope
- photoreceptor inner segments
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pcm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- social behavior
- positive regulation of intracellular protein transport
- cilium morphogenesis
- centrosome cycle
- microtubule anchoring
- neuronal stem cell maintenance
- interkinetic nuclear migration
- neuron migration
- intraflagellar transport involved in cilium morphogenesis
- negative regulation of neurogenesis
- cytoplasmic microtubule organization
- microtubule anchoring at centrosome
- protein localization to centrosome
Cellular Component
Where in the cell the gene product is active
- cilium basal body
- centriolar satellite
- nucleoplasm
- pericentriolar material
- centrosome
- nuclear membrane
- apical part of cell
- centriole
- cytoplasm
- membrane
- cytosol
- macromolecular complex
- ciliary transition zone
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- binding, bridging