GAS8 Gene Summary [Human]
This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposite orientation. This gene is a putative tumor suppressor gene. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Details
| Type | Processed Transcript |
| Official Symbol | GAS8 |
| Official Name | growth arrest specific 8 [Source:HGNC Symbol;Acc:HGNC:4166] |
| Ensembl ID | ENSG00000141013 |
| Bio databases IDs | |
| Aliases | growth arrest specific 8 |
| Synonyms | CILD33, DRC4, GAS11, growth arrest specific 8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GAS8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- enzyme binding
- Growth-arrest specific micro-tubule binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell cancer
- epithelial cancer
- cancer
- hepatocellular carcinoma
- liver cancer
- primary ciliary dyskinesia type 33
- epithelial basal cell carcinoma
- melanoma
- melanoma cancer
- non-melanoma skin cancer
regulates
- SMO dimer
role in cell
- proliferation
- binding
- assembly
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- microtubule cytoskeleton
- intracellular membrane-bounded organelle
- cilia
- Plasma Membrane
- basal bodies
- Golgi Apparatus
- flagella
- microtubules
- axonemes
- cytosol
- sperm tail
- glial cell projections
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GAS8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm motility
- cilium movement involved in cell motility
- negative regulation of cell proliferation
- positive regulation of smoothened signaling pathway
- protein localization
- epithelial cilium movement
- axoneme assembly
- establishment of localization in cell
- brain development
- determination of left/right symmetry
Cellular Component
Where in the cell the gene product is active
- motile cilium
- cilium basal body
- cilium
- cytosol
- Golgi apparatus
- sperm flagellum
- extracellular region
- axoneme
- plasma membrane
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding
- microtubule binding