Pitpnc1 Gene Summary [Mouse]
Enables phosphatidylinositol binding activity. Predicted to be involved in phospholipid transport and signal transduction. Predicted to act upstream of or within phosphatidylinositol metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina; and small intestine. Orthologous to human PITPNC1 (phosphatidylinositol transfer protein cytoplasmic 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pitpnc1 |
| Official Name | phosphatidylinositol transfer protein, cytoplasmic 1 [Source:MGI Symbol;Acc:MGI:1919045] |
| Ensembl ID | ENSMUSG00000040430 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol transfer protein, cytoplasmic 1 |
| Synonyms | 1110020B03RIK, 5830436L09Rik, C330017I21Rik, Dnr411, M-RDGB-beta, M-RDGB-β, phosphatidylinositol transfer protein cytoplasmic 1, phosphatidylinositol transfer protein, cytoplasmic 1, RDGBB, RDGBB1, RDGB-BETA, RDGB-β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pitpnc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SRPBCC domain
- lipid transporter
- phospholipid binding
- binding protein
- phospholipid transporter
- Phosphatidylinositol transfer protein
- phosphatidylinositol transporter
- protein binding
- phosphatidylinositol binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- non-insulin-dependent diabetes mellitus
- schizophrenia
- chronic central serous chorioretinopathy
- pervasive developmental disorder
- duodenal ulcer
- Rett syndrome
regulates
- phosphatidylinositol
- phospholipid
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pitpnc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- phospholipid transport
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol binding
- phosphatidic acid binding
- phosphatidylinositol transporter activity
- phosphatidylcholine transporter activity