Esrrb Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II complex binding activity. Involved in several processes, including morula formation; photoreceptor cell maintenance; and regulation of macromolecule biosynthetic process. Acts upstream of or within embryonic placenta development; trophectodermal cell proliferation; and trophectodermal cellular morphogenesis. Located in condensed chromosome; cytoplasm; and nucleus. Part of integrator complex. Is expressed in several structures, including central nervous system; early conceptus; endocrine gland; gonad; and sensory organ. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 35. Orthologous to human ESRRB (estrogen related receptor beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Esrrb |
| Official Name | estrogen related receptor, beta [Source:MGI Symbol;Acc:MGI:1346832] |
| Ensembl ID | ENSMUSG00000021255 |
| Bio databases IDs | |
| Aliases | estrogen related receptor, beta |
| Synonyms | DFNB35, ERR2, ERRb, Err beta, Err β, ESRL2, estrogen related receptor, beta, estrogen-related receptor beta, estrogen related receptor, β, estrogen-related receptor β, Estrrb, LOC108351278, LOC108351279, NR3B2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Esrrb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- enzyme binding
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- ligand-binding domain
- ligand-dependent nuclear receptor
- Ligand-binding domain of nuclear hormone receptor
- transcription factor activity
Pathways
Biological processes and signaling networks where the Esrrb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- chorioallantoic membrane fusion failure
- autosomal recessive deafness type 35
- cervical cancer
- metastatic prostate cancer
- familial nonsyndromic hearing impairment
- autosomal recessive deafness
- attention deficit hyperactivity disorder
- growth failure
- renal clear cell adenocarcinoma
role in cell
- quantity
- proliferation
- cell death
- expression in
- phosphorylation in
- migration
- differentiation
- self-renewal
- pluripotency
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- chromosome
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Esrrb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stem cell maintenance
- inner ear development
- regulation of transcription, DNA-dependent
- cell dedifferentiation
- positive regulation of transcription from RNA polymerase II promoter
- embryonic placenta development
- regulation of transcription from RNA polymerase II promoter
- intracellular steroid hormone receptor signaling pathway
- positive regulation of transcription, DNA-dependent
- photoreceptor cell maintenance
- negative regulation of stem cell differentiation
- regulation of stem cell division
- stem cell division
Cellular Component
Where in the cell the gene product is active
- condensed chromosome
- nucleus
- cytoplasm
- cytosol
- chromatin
- integrator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- estrogen response element binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- steroid binding
- RNA polymerase II core binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- sequence-specific DNA binding transcription factor activity
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- steroid hormone receptor activity