Psmd6 Gene Summary [Mouse]
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome accessory complex. Is expressed in early conceptus. Orthologous to human PSMD6 (proteasome 26S subunit, non-ATPase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psmd6 |
| Official Name | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 [Source:MGI Symbol;Acc:MGI:1913663] |
| Ensembl ID | ENSMUSG00000021737 |
| Bio databases IDs | |
| Aliases | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 |
| Synonyms | 2400006A19RIK, FLJ30168, LOC103693817, p42A, P44s10, PFAAP4, proteasome 26S subunit, non-ATPase 6, proteasome (prosome, macropain) 26S subunit, non-ATPase, 6, RPN7, S10, S10a, SGA-113M |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psmd6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
- PCI domain
- enzyme
- protein binding
- 26S proteasome subunit RPN7
Pathways
Biological processes and signaling networks where the Psmd6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- acute graft-vs-host disease
- infection by HIV-1
regulates
role in cell
- apoptosis
- molecular cleavage in
- necroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- cytosol
- nucleoplasm
- cytoplasmic droplets
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psmd6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- proteasome regulatory particle
- cytosol
- proteasome accessory complex
- proteasome complex
- secretory granule lumen
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding