Arhgef38 Gene Summary [Mouse]

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in cytoplasm. Orthologous to human ARHGEF38 (Rho guanine nucleotide exchange factor 38). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Arhgef38
Official Name
Rho guanine nucleotide exchange factor (GEF) 38 [Source:MGI Symbol;Acc:MGI:1924919]
Ensembl ID
ENSMUSG00000040969
Bio databases IDs NCBI: 77669 Ensembl: ENSMUSG00000040969
Aliases Rho guanine nucleotide exchange factor (GEF) 38
Synonyms 9130221D24Rik, D630013G24Rik, FLJ43963, LOC102556447, RGD1311728, Rho guanine nucleotide exchange factor 38
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgef38 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • RhoGEF
  • protein binding
  • BAR domain
  • Bin/Amphiphysin/Rvs domain
  • RhoGEF domain
  • Src Homology 3 domain superfamily

Pathways

Biological processes and signaling networks where the Arhgef38 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
  • THZ531
disease
  • COVID-19
  • idiopathic scoliosis
  • chronic obstructive pulmonary disease
  • estrogen receptor positive breast cancer
  • breast cancer

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Unknown

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgef38 gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • cytoplasm

Molecular Function

What the gene product does at the molecular level
  • guanyl-nucleotide exchange factor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.