Phf8 Gene Summary [Mouse]
Predicted to enable several functions, including histone demethylase activity; methylated histone binding activity; and transition metal ion binding activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; chromatin remodeling; and positive regulation of macromolecule biosynthetic process. Predicted to be located in nuclear membrane; nucleolus; and nucleoplasm. Is expressed in several structures, including brain; early conceptus; olfactory epithelium; ovary; and vibrissa follicle. Used to study syndromic X-linked intellectual disability Siderius type. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Siderius type. Orthologous to human PHF8 (PHD finger protein 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phf8 |
| Official Name | PHD finger protein 8 [Source:MGI Symbol;Acc:MGI:2444341] |
| Ensembl ID | ENSMUSG00000041229 |
| Bio databases IDs | |
| Aliases | PHD finger protein 8 |
| Synonyms | 9830141C09Rik, JHDM1F, KDM7B, LOC102550078, mKIAA1111, MRXSSD, PHD finger protein 8, RGD1561065, ZNF422 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Phf8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- Jumonji helical domain
- histone binding
- 2-oxoglutarate:oxygen oxidoreductase
- protein binding activity, bridging
- iron ion binding
- chromatin binding
- enzyme
- protein binding
- RmlC-like cupin superfamily
- zinc ion binding
- PHD finger superfamily
- histone demethylase activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Siderius X-linked mental retardation syndrome
- mental retardation
- hereditary disorder
- rotator cuff injury
role in cell
- binding in
- expression in
- proliferation
- accumulation in
- number
- G1/S phase transition
- formation
- invasion by
- transactivation in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Phf8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of chromatin silencing at rDNA
- chromatin remodeling
- protein demethylation
- positive regulation of transcription, DNA-dependent
- G1/S transition of mitotic cell cycle
- brain development
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase I promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- histone demethylase activity (H4-K20 specific)
- methylated histone residue binding
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
- chromatin binding
- protein binding
- transcription cofactor activity
- iron ion binding
- histone demethylase activity (H3-K9 specific)
- histone demethylase activity
- histone demethylase activity (H3-K27 specific)
- histone demethylase activity (H3-K36 specific)