Tead1 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic organ development; hippo signaling; and transition between fast and slow fiber. Located in nucleus. Part of TEAD-YAP complex. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and tooth. Human ortholog(s) of this gene implicated in Sveinsson chorioretinal atrophy. Orthologous to human TEAD1 (TEA domain transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tead1 |
| Official Name | TEA domain family member 1 [Source:MGI Symbol;Acc:MGI:101876] |
| Ensembl ID | ENSMUSG00000055320 |
| Bio databases IDs | |
| Aliases | TEA domain family member 1 |
| Synonyms | 2610024B07Rik, AA, B230114H05RIK, DKFZP434N1435, Gtrgeo5, LOC102723893, mTEF-1, NTEF-1, REF1, TCF-13, TEA domain family member 1, TEA domain transcription factor 1, TEF-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tead1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- transcription regulator
- nucleic acid binding
- alpha helix
- protein binding
- TEA/ATTS domain
- sequence-specific DNA binding
- proline rich domain
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- YAP binding domain
- zinc finger domain
- transcription factor activity
- STY-rich domain
Pathways
Biological processes and signaling networks where the Tead1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- neoplasia
- cancer
- epithelial cancer
- schizophrenia
- osteoarthritis
- Alzheimer disease
- soft tissue sarcoma cancer
- liver cancer
- liver neoplasia
role in cell
- expression in
- phosphorylation in
- cell death
- apoptosis
- growth
- quantity
- proliferation
- accumulation
- senescence
- 5-fluorouracil sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tead1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell growth
- macromolecular complex assembly
- positive regulation of transcription, DNA-dependent
- hippo signaling cascade
- embryonic organ development
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity