Kif21b Gene Summary [Mouse]
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels and retrograde dendritic transport. Acts upstream of or within corpus callosum development. Is active in glutamatergic synapse and postsynaptic endosome. Is expressed in central nervous system; dorsal root ganglion; and neural retina. Orthologous to human KIF21B (kinesin family member 21B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kif21b |
| Official Name | kinesin family member 21B [Source:MGI Symbol;Acc:MGI:109234] |
| Ensembl ID | ENSMUSG00000041642 |
| Bio databases IDs | |
| Aliases | kinesin family member 21B |
| Synonyms | 2610511N21Rik, KIAA0449, kinesin family member 21B, mKIAA0449 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kif21b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Flagellar FliJ protein
- Domain of unknown function (DUF4515)
- PspA/IM30 family
- Ezrin/radixin/moesin, alpha-helical domain
- Myosin and Kinesin motor domain
- WD domain, G-beta repeat
- WD40
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Kinesin motor, catalytic domain
- microtubule binding
- WD40 repeats
- Trichohyalin-plectin-homology domain
- stalk region
- Kinesin motor domain
- regulatory coiled-coil domain found in the kinesin-like KIF21 family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- brain cancer
- schizophrenia
- neurodevelopmental disorder
- pervasive developmental disorder
- bipolar disorder
- major depression
- primary biliary cirrhosis
- ankylosing spondylitis
- inflammatory bowel disease
- group 3 medulloblastoma
role in cell
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- glutaminergic synapse
- endosomes
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kif21b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microtubule-based movement
Cellular Component
Where in the cell the gene product is active
- growth cone
- dendrite
- cytoplasmic vesicle
- kinesin complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- microtubule motor activity
- microtubule binding