Mknk1 Gene Summary [Mouse]
This gene encodes a serine-threonine protein kinase that is activated by extracellular signal-regulated kinase or p38 mitogen-activated protein kinases, and it may function in cytokine and environmental stress responses. This kinase is required for phosphorylation of eukaryotic translation initiation factor 4E but it is not required for cell growth during development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013]
Details
| Type | Protein Coding |
| Official Symbol | Mknk1 |
| Official Name | MAP kinase-interacting serine/threonine kinase 1 [Source:MGI Symbol;Acc:MGI:894316] |
| Ensembl ID | ENSMUSG00000028708 |
| Bio databases IDs | |
| Aliases | MAP kinase-interacting serine/threonine kinase 1 |
| Synonyms | 2410048M24Rik, MAP kinase-interacting serine/threonine kinase 1, MAPK interacting serine/threonine kinase 1, MNK1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mknk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein Kinases, catalytic domain
- MAPK binding site
- ATP binding
- protein binding
- Protein kinase domain
Pathways
Biological processes and signaling networks where the Mknk1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- neoplasia
- advanced non-small cell lung cancer
- thrombocytopenia
- septic shock
- diabetes mellitus
- stage IV lung squamous cell carcinoma
- advanced lung squamous cell carcinoma
- metastatic lung adenocarcinoma
- advanced non-small cell lung adenocarcinoma
role in cell
- expression in
- activation in
- apoptosis
- aggregation
- proliferation
- phosphorylation in
- cell viability
- synthesis in
- production in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mknk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- protein autophosphorylation
- peptidyl-serine phosphorylation
- protein phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- protein binding
- metal ion binding
- calmodulin-dependent protein kinase activity
- protein serine/threonine kinase activity
- calcium-dependent protein serine/threonine kinase activity