Rnf10 Gene Summary [Mouse]
The protein encoding this gene is a member of the really interesting new gene finger protein family. Members of this family contain protein motifs similar to zinc finger domains and are involved in many processes that include transcriptional regulation, DNA repair and signal transduction. Expression of this gene is upregulated during neuronal differentiation of cultured cells, and inhibition of its expression impairs differentiation and cell cycle exit, providing evidence for a function in neuronal differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Details
| Type | Protein Coding |
| Official Symbol | Rnf10 |
| Official Name | ring finger protein 10 [Source:MGI Symbol;Acc:MGI:1859162] |
| Ensembl ID | ENSMUSG00000041740 |
| Bio databases IDs | |
| Aliases | ring finger protein 10 |
| Synonyms | mKIAA0262, RIE2, ring finger protein 10, Ring protein 10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleic acid binding
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- enzyme
- Ring finger domain
- protein binding
- sequence-specific DNA binding
- RING-type zinc-finger
- double-stranded DNA binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- metastasis
- glioblastoma
- glioblastoma cancer
- organismal death
- head and neck neoplasia
- diabetic nephropathy
- infection by HIV-1
phenotypes
- abnormal QT variability
- abnormal auditory brainstem response
- abnormal behavior
- abnormal bone structure
- abnormal coat/ hair morphology
- abnormal eye morphology
- abnormal gait
- abnormal kidney morphology
- abnormal lens morphology
- abnormal retinal blood vessel morphology
- abnormal retinal inner nuclear layer morphology
- abnormal retinal vasculature morphology
- abnormal sleep behavior
- abnormal spleen morphology
- abnormal tibia morphology
- absent pinna reflex
- absent vibrissae
- anophthalmia
- cataract
- convulsive seizures
- decreased Ly6C-positive immature NK cell number
- decreased body length
- decreased circulating HDL cholesterol level
- decreased circulating alkaline phosphatase level
- decreased circulating aspartate transaminase level
- decreased circulating cholesterol level
- decreased circulating creatinine level
- decreased circulating glucose level
- decreased circulating iron level
- decreased circulating serum albumin level
- decreased circulating total protein level
- decreased circulating triglyceride level
- decreased effector memory T-helper cell number
- decreased exploration in new environment
- decreased grip strength
- decreased hematocrit
- decreased hemoglobin content
- decreased lean body mass
- decreased lymphocyte cell number
- decreased mean corpuscular hemoglobin
- decreased mean corpuscular hemoglobin concentration
- decreased prepulse inhibition
- decreased spleen weight
- decreased startle reflex
- decreased thigmotaxis
- decreased total body fat amount
- decreased total retina thickness
- enlarged heart
- glycogen deposition
- hyperactivity
- hypoactivity
- immune system phenotype
- improved glucose tolerance
- increased CD4-positive alpha beta T cell number
- increased NK T cell number
- increased T cell number
- increased T-helper cell number
- increased body length
- increased bone mineral content
- increased bone mineral density
- increased circulating chloride level
- increased circulating creatinine level
- increased circulating sodium level
- increased circulating triglyceride level
- increased circulating unsaturated transferrin level
- increased erythrocyte cell number
- increased fluid intake
- increased grip strength
- increased heart left ventricle size
- increased heart rate
- increased heart weight
- increased large unstained cell number
- increased lean body mass
- increased liver weight
- increased monocyte cell number
- increased red blood cell distribution width
- increased total body fat amount
- increased vertical activity
- limb grasping
- preweaning lethality incomplete penetrance
- prolonged PQ interval
- shortened ST segment
- thin ventricular wall
- abnormal adipose tissue amount
- abnormal body length
- abnormal bone mineralization
- abnormal circulating HDL cholesterol level
- abnormal circulating alkaline phosphatase level
- abnormal circulating creatinine level
- abnormal circulating glucose level
- abnormal circulating iron level
- abnormal circulating triglyceride level
- abnormal circulating unsaturated transferrin level
- abnormal grip strength
- abnormal heart rate
- abnormal large unstained cell number
- abnormal lean body mass
- abnormal locomotor activation
- abnormal lymphocyte cell number
- abnormal mean corpuscular hemoglobin
- abnormal mean corpuscular hemoglobin concentration
- abnormal monocyte cell number
- abnormal prepulse inhibition
- abnormal response to new environment
- abnormal spleen weight
- abnormal startle reflex
- decreased body weight
- increased body weight
- increased circulating HDL cholesterol level
- increased circulating cholesterol level
- increased mean platelet volume
role in cell
- expression in
- binding in
- proliferation
- accumulation in
- degradation in
- focus formation in
- reverse transcription in
- polyubiquitination in
- focus formation
- reverse transcription
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- ribosome
- Nucleus
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of Schwann cell proliferation
- positive regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- protein monoubiquitination
- protein autoubiquitination
- positive regulation of myelination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosolic ribosome
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- transcription regulatory region sequence-specific DNA binding