Rnf10 Gene Summary [Mouse]
The protein encoding this gene is a member of the really interesting new gene finger protein family. Members of this family contain protein motifs similar to zinc finger domains and are involved in many processes that include transcriptional regulation, DNA repair and signal transduction. Expression of this gene is upregulated during neuronal differentiation of cultured cells, and inhibition of its expression impairs differentiation and cell cycle exit, providing evidence for a function in neuronal differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Details
| Type | Protein Coding |
| Official Symbol | Rnf10 |
| Official Name | ring finger protein 10 [Source:MGI Symbol;Acc:MGI:1859162] |
| Ensembl ID | ENSMUSG00000041740 |
| Bio databases IDs | |
| Aliases | ring finger protein 10 |
| Synonyms | mKIAA0262, RIE2, ring finger protein 10, Ring protein 10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleic acid binding
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- enzyme
- Ring finger domain
- protein binding
- sequence-specific DNA binding
- RING-type zinc-finger
- double-stranded DNA binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- metastasis
- glioblastoma
- glioblastoma cancer
- organismal death
- head and neck neoplasia
- diabetic nephropathy
- infection by HIV-1
role in cell
- expression in
- binding in
- proliferation
- accumulation in
- degradation in
- focus formation in
- reverse transcription in
- polyubiquitination in
- focus formation
- reverse transcription
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- ribosome
- Nucleus
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of Schwann cell proliferation
- positive regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- protein monoubiquitination
- protein autoubiquitination
- positive regulation of myelination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosolic ribosome
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- transcription regulatory region sequence-specific DNA binding