Mkrn3 Gene Summary [Mouse]
Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in nucleus. Is expressed in gut; nervous system; and sensory organ. Used to study central precocious puberty 2. Human ortholog(s) of this gene implicated in central precocious puberty 2. Orthologous to human MKRN3 (makorin ring finger protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mkrn3 |
| Official Name | makorin, ring finger protein, 3 [Source:MGI Symbol;Acc:MGI:2181178] |
| Ensembl ID | ENSMUSG00000070527 |
| Bio databases IDs | |
| Aliases | makorin, ring finger protein, 3 |
| Synonyms | CPPB2, D15S9, D7H15S9-1, makorin ring finger protein 3, makorin, ring finger protein, 3, RNF63, ZFP127, ZNF127 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mkrn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- E3 ubiquitin-protein ligase makorin, C-terminal
- CCCH-type zinc finger
- ubiquitin protein ligase activity
- enzyme
- Ring finger domain
- protein binding
- identical protein binding
- RNA binding
- zinc finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- zinc finger domain
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- tumorigenesis
- central precocious puberty type 2
- organismal death
- pervasive developmental disorder
- Prader-Willi syndrome
role in cell
- expression in
- proliferation
- number
- morphology
- ubiquitination in
- degradation in
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mkrn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- protein ubiquitination
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA binding
- metal ion binding